Neurodermatitis
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Abstract
Neurodermatitis, or lichen simplex chronicus (LSC), is a chronic inflammatory skin disorder that significantly impacts quality of life due to intense pruritus, sleep disturbance, and cosmetic concerns. It is characterized by localized lichenified plaques that result from repeated scratching. We report a case of a 33-year-old female presenting with chronic itching on the dorsal aspects of both feet for one year. Symptoms worsened during rest, and the patient was unable to resist scratching until excoriations occurred. She had previously attempted self-medication with gentamicin and hydrocortisone ointments without improvement. Physical examination revealed multiple well-demarcated lesions with hyperpigmented macules, fine scaling, and lichenification. A clinical diagnosis of neurodermatitis was established, with differential diagnoses including lichen planus and psoriasis. Management consisted of topical corticosteroid combined with salicylic acid, oral antihistamine, and patient education to avoid scratching and maintain skin hygiene. Prognosis was favorable in terms of life and function, although healing was variable depending on treatment adherence and psychological factors. This case highlights the importance of breaking the itch–scratch cycle, patient counseling, and family support in the management of neurodermatitis
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References
1. Shafiyev J, Gahramanov I. Evaluating duloxetine for pruritus and psychiatric comorbidities in lichen simplex chronicus. Arch Dermatol Res [Internet]. 2025; Available from: https://link.springer.com/article/10.1007/s00403-024-03775-7
2. Moshkovich M, Andrade LF, Anderson M, ... Lichen Simplex Chronicus: Clinical Perspectives and Emerging Therapeutic Strategies: M. Moshkovich et al. [Internet]. American Journal of …. Springer; 2025. Available from: https://link.springer.com/article/10.1007/s40257-025-00979-z
3. Basamat A. Unique phenotypic–genotypic correlation in Saudi patients with ALMS1 mutations. Sjo. 2022;(8.5.2017):2003–5.
4. Starace M, Iorizzo M, Mandel VD, Bruni F, ... Scalp dysaesthesia and lichen simplex chronicus: diagnostic and therapeutic update with literature review. Clin … [Internet]. 2022; Available from: https://academic.oup.com/ced/article-abstract/47/1/3/6598111
5. Alanazi F, Kashoo FZ, Alduhishy A, Aldaihan M, Ahmad F, Alanazi A. Incidence rate, risk factors, and management of Bell’s palsy in the Qurayyat region of Saudi Arabia. PeerJ. 2022;10:1–13.
6. Lee W, Chaudhary F, ... Environmental Influences on Atopic Eczema [Internet]. Journal of environmental …. pmc.ncbi.nlm.nih.gov; 2024. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11328973/
7. Dave S, DAHLSTROM JJ. Neurogenic Shock. In Treasure Island (FL); 2023.
8. Aitella E, Martinis M De, Romano C, Azzellino G, ... Neurogenic Inflammation in Allergic Contact Dermatitis [Internet]. Biomedicines. mdpi.com; 2025. Available from: https://www.mdpi.com/2227-9059/13/3/656
9. Luschkova D, Zeiser K, Ludwig A, ... Neurodermitis ist eine Umwelterkrankung [Internet]. opus.bibliothek.uni-augsburg.de; 2021. Available from: https://opus.bibliothek.uni-augsburg.de/opus4/files/90011/90011.pdf
10. Burghardt ME, Heinzelmann J, Stein M, ... Simultaneous Muraine Sutures and Excimer Laser-Assisted Penetrating Keratoplasty for Acute Keratoconus [Internet]. Journal of Clinical …. mdpi.com; 2024. Available from: https://www.mdpi.com/2077-0383/13/13/3792
11. Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin Wound Healing: An Update on the Current Knowledge and Concepts. Eur Surg Res. 2017;58(1–2):81–94.
12. Gulati R, Behfar A, Narula J, Kanwar A, Lerman A, Cooper L, et al. Acute Myocardial Infarction in Young Individuals. Mayo Clin Proc [Internet]. 2020;95(1):136–56. Available from: https://doi.org/10.1016/j.mayocp.2019.05.001
13. Mir-Bonafé JF, Piquero-Casals J, Prudkin L, ... Use of Topical Corticosteroids in the Treatment of Noninfectious Inflammatory Dermatoses of the Scalp: A Survey of Practicing Dermatologists and Dermatology …. Clin Cosmet … [Internet]. 2024; Available from: https://www.tandfonline.com/doi/abs/10.2147/CCID.S448016
14. Bartley B, Pierce C, Hivnor C, Valdes-Rodriguez R. Topical Medications for Chronic Itch in Older Patients: Navigating a Pressing Need. Drugs &Aging [Internet]. 2025; Available from: https://link.springer.com/article/10.1007/s40266-024-01174-1
15. Langenbruch A, Augustin M, ... Care Situation of Female Patients with different Degrees of Severity of Neurodermatitis: Results of the multicenter Study" AtopicHealth2". JOURNAL …. … ST, HOBOKEN 07030-5774, NJ USA; 2021.
16. Bewley A, Barlow R. Nodular prurigo. Psychodermatology Clin Pract [Internet]. 2021; Available from: https://link.springer.com/chapter/10.1007/978-3-030-54307-5_15
17. Altunay İK, Özkur E, Uğurer E, Baltan E, Aydın Ç, ... More than a skin disease: stress, depression, anxiety levels, and serum neurotrophins in lichen simplex chronicus [Internet]. Anais Brasileiros de …. Elsevier; 2021. Available from: https://www.sciencedirect.com/science/article/pii/S0365059621002178
18. Adams SH, Huang NT, Bersani T, Alpert S. Lichen simplex chronicus of the eyelid: A case report and literature review [Internet]. American Journal of …. Elsevier; 2021. Available from: https://www.sciencedirect.com/science/article/pii/S2451993621002462
19. Almokhtar A. Adwas, J.M. Jbireal, Azab Elsayed Azab. Anxiety: Insights into Signs, Symptoms, Etiology, Pathophysiology, and Treatment. East African Sch J Med Sci. 2019;02(10):580–580.
20. Ambika H, Vinod CS, Sushmita J. Case Report A Case of Neurodermatitis Circumscipta of Scalp Presenting as Patchy Alopecia [Internet]. academia.edu. Available from: https://www.academia.edu/download/108441842/0974-7753.12297120231206-1-664rq2.pdf